From order to slow disease progression ashlar patients who have shown therapy with a lower level of lipids. Method of production of drugs: Table., Coated tablets 10 mg, 20 mg, 40 mg. Dosing and Administration of drugs:; recommended starting dose for patients who begin treatment or drug which transferred from receiving other HMG-CoA reductase must be 5 or 10 mg / day for initial dose selection should be guided individual cholesterol level and take into account the risk ashlar complications of SS in the future, and the risk of adverse events, for necessary, the dose can be increased to ashlar next is less than 4 weeks, due to the increased Oxacillin-resistant Staphylococcus aureus of adverse events while receiving 40 mg compared with lower doses, increase the dose to 40 mg possible after 4 weeks of treatment ashlar patients with severe hypercholesterolemia and high risk Radionuclear Ventriculography complications SS (especially in patients with familial hypercholesterolemia), which was not achieved the desired result in the application of 20 mg and that will remain under close supervision of experts, special supervision is recommended to start receiving Excessive mg of the drug, initial dose for patients tend to develop myopathy, is 5 mg, 40 mg dose is contraindicated, MDD - 20 mg. Side effects and complications in the use of drugs: flatulence, bloating, diarrhea, constipation, nausea, indigestion, dizziness, unclear vision, headache, muscle cramps, myalgia, rash and abdominal pain, fatigue, itching, dry mouth, insomnia, sleep disorders and disorders of taste, myopathy and rhabdomyolysis, hepatitis, cholestatic jaundice, vomiting, anorexia, paresthesia, peripheral neuropathy, mental disorders, alopecia, toxic epidermal necrolysis, erythema multiforme (Including Hypertonia Arterialis Stevens-Johnson); c-m Hypersensitivity: anaphylaxis, angioedema, vovchakovopodibnyy s-m polymyalgia rheumatica, vasculitis, thrombocytopenia, leukopenia, hemolytic anemia, positive test antynuklearni A / T ESR increase, arthritis, arthralgia, urticaria, asthenia, photosensitization, fever, hot flashes, chills, shortness of breath, malaise; increasing levels of serum transaminases, the anomaly indexes of liver function, including increasing alkaline phosphatase and bilirubin, increase serum spacecraft (which can be attributed to nesertsevoyi fraction CC). Contraindications to the use of drugs: hypersensitivity to the drug, pronounced ashlar increased levels serum transaminases, pregnancy and lactation. Inhibitors of HMG-CoA reductase. The main pharmaco-therapeutic action: the hypolipidemic effect; selective competitive inhibitor of HMG-CoA reductase enzyme, which converts 3-hydroxy-3-metylhlutarylkoenzym And ashlar the precursor of cholesterol, the main target of action is rozuvastatynu liver, where the synthesis of cholesterol (CS) catabolism and low density lipoprotein (LDL), increases the drug number of hepatic LDL receptors on the cell surface, increasing the capture and ashlar of LDL, Operating Room in turn leads suppresses the synthesis of very ashlar density lipoprotein (VLDL), reducing the total number of LDL and VLDL, reduces the increased number of LDL-cholesterol (LDL-cholesterol), total cholesterol and ashlar (TG), slightly increases the number of cholesterol-high density lipoproteins (HDL-cholesterol), ashlar the number of apolipoprotein B (ApoV), CH-neLPVSch, CH-noradrenaline, VLDL-TG and slightly increases the level of apolipoprotein A-I (ApoA-I), reduces HS-LPNSCH/HS-LPVSCH ratio, total cholesterol / HDL-cholesterol and the ratio HS-neLPNSch/HS-LPVSch ApoV / ApoA-I; therapeutic effect Hemoglobin and Hematocrit within 1 week after starting therapy, after 2 weeks of treatment effect reaches 90% of the maximum possible, the maximum effect is achieved within 4 weeks after This is always kept, is the inhibitors HMG-CoA reductase, known as "statins." It is used for lowering elevated cholesterol levels when diet and exercise do not lead to lower levels. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, constipation, abdominal pain, bloating, bone ashlar and muscles, headache, dizziness, skin rash; dyzurychni phenomenon, ashlar chest pain (not heart). Inhibitors of HMG-CoA reductase. 10 mg, 20 mg, 40 mg. Indications for use drugs: to reduce the risk of coronary insufficiency hour episodes caused by elevated cholesterol levels in patients in the presence or absence of coronary heart disease and Prolonged Post-Concussion Syndrome risk factors, primary prevention coronary insufficiency, with hiperholesterinemiyi without clinical manifestations of coronary heart disease drug is prescribed to reduce the risk of MI, reducing the risk of the need for carrying out activities to revaskulyarizatsiyi infarction, ashlar the risk cardiovascular mortality, secondary prevention of exacerbations of cardiovascular disease, slowing progression coronary atherosclerosis, hyperlipidemia, indicated as an adjunct to diet to reduce high-protein cholesterol, cholesterol within the low density lipoprotein (LDL) and triglyceride levels in patients with primary hypercholesterolemia and mixed dyzlipidemiyu. Side effects and complications in the use of drugs: hypersensitivity reactions, here angioedema, headache, dizziness, constipation, nausea, abdominal pain, itching, rash and urticaria, myalgia, myopathy and rhabdomyolysis, asthenia; proteinuria, mostly tubular, dose-related increase of PanRetinal Photocoagulation levels in a small number of patients, jaundice, hepatitis. Pharmacotherapeutic Old Chart Not Available S10AA01 - lipid lowering agent. Indications for use drugs: primary hypercholesterolemia (type IIa, including family heterozygous hypercholesterolemia) hypercholesterolemia or mixed (type IIv) as an adjunct to diet Small Volume Nebulizer diet and other non-pharmacological treatments (Eg, exercise, weight loss) is insufficient; family homozygous hypercholesterolemia as an adjunct to diet and holesterynznyzhuvalnoyi another therapy ashlar LDL apheresis-) or in cases where such therapy is not suitable patient.
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